What does do not turn off target mean
Android Downloading Do Not Turn off Target – If you are an Android user, you may have experienced or you are encountering this issue – downloading do not turn off target. This is an error message that often happens on Samsung and some Nexus devices. Most users reported the device unexpectedly rebooted into a screen with the error.
The issue happens mainly because you press the wrong button combinations to access the recovery mode of your phone. On Samsung and Nexus devices, the key combination to enter this mode is Power + Home + Volume Up, But if you press Volume Down instead of Volume Up, the phone will enter the download mode instead of recovery mode and you see the error message.
Besides, downloading do not turn off target S7/S6/, etc. can be triggered by a software glitch. Well then, how can you fix this error? The simple solutions are introduced below and you can try them to easily solve your issue.
Do you not turn off target?
What Does it Mean “Downloading Do Not Turn Off Target” – If your phone says downloading don’t turn off target, it always means your device is in Download Mode, You can enter this mode by holding the Power, Home, and Volume Down buttons simultaneously.
- Once you enter the Samsung Odin Mode, you will be asked if you want to continue and flash a new ROM or firmware onto the device or exit the mode.
- You can navigate through this mode using the Volume Up and Volume Down buttons.
- But the issue occurs, when the phone displays the ‘downloading do not turn off target’ message instead of leaving the Download mode.
Why does my phone say downloading do not turn off target? The software glitch is usually the reason why Samsung phones display this message, so resolving it requires some previous knowledge of how the Android OS works. There are several methods you can use to fix the problem once your device gets stuck on the “downloading do not turn off target” message.
What does sometimes off target mean
Inaccurate, or inaccurately predicted.
What does off target mean in biology?
Off-target activity is biological activity of a drug that is different from and not at that of its intended biological target. It most commonly contributes to side effects. However, in some cases, off-target activity can be taken advantage of for therapeutic purposes.
Why do people use target?
Target strikes a great balance between Walmart and higher end stores like Macy’s. They have good, well-built products and a nice selection at reasonable prices. They also have a store which (in my experience) is more pleasant to shop in over other big box stores.
Why will my Samsung not turn off?
Option 2. Hard Restart Samsung Phone – If your Samsung phone is not turning off because it’s frozen, you can do a hard restart to resolve the problem. Samsung phones or devices usually freeze when too many apps open simultaneously. When this happens, you sometimes need to force it to restart for it to function again. If the problem is still there, kindly refer to the other methods.
What is Odin mode
From Wikipedia, the free encyclopedia
Odin 3.14 running on a Windows 11 machine, with a device ready for flashing plugged in. | |
Developer(s) | Samsung |
---|---|
Stable release | 3.14.1 / February 2020 ; 3 years ago |
Operating system | Windows |
Available in | English |
Odin is a utility software program developed and used by Samsung internally which is used to communicate with Samsung devices in Odin mode (also called download mode ). It can be used to flash a custom recovery firmware image (as opposed to the stock recovery firmware image) to a Samsung Android device,
- Odin is also used for unbricking certain Android devices.
- Odin is the Samsung proprietary alternative to Fastboot,
- There is no account of Samsung ever having officially openly released Odin, though it is mentioned in the developer documents for Samsung Knox SDK and some documents even instruct users to use Odin.
Some other docs on Knox SDK reference “engineering firmware”, which presumably can be a part of the Knox SDK along with Odin. Publicly available binaries are believed to be the result of leaks. The tool is not intended for consumers, but for Samsung’s own personnel and approved repair centers.
What is a synonym for off-target
Synonyms of off-target (adj. askew. adrift. astray. far-off. inaccurate.
What is the off targeting effect?
1 Introduction – Genome editing tools hold great promise in treating genetic and non-genetic diseases. Early studies utilize zinc finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) for genome editing ( Urnov et al., 2010 ; Joung and Sander, 2013 ; Shamshirgaran et al., 2022 ).
- ZFNs and TALENs depend on protein engineering of DNA-binding domains to recognize and edit specific DNA sequences.
- This engineering process could be ineffective, tedious and expensive, limiting the application of genome editing.
- The above problems were recently solved by the emergence of the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system.
CRISPR/Cas9 is a class of ribonucleoprotein complexes formed by a Cas9 protein and a single guide RNA (sgRNA) ( Jinek et al., 2012 ; Cho et al., 2013 ; Cong et al., 2013 ; Wang et al., 2016a ). Cas9 can create DNA cleavage at desired genomic positions that are guided by precise base pairing between sgRNA and DNA, adjacent to a protospacer-adjacent motif (PAM) ( Jinek et al., 2012 ; Cho et al., 2013 ; Cong et al., 2013 ; Wang et al., 2016a ).
Designing sgRNA is more convenient, programmable and cost-effective than designing DNA binding domains, thus CRISPR/Cas9 is more favored than ZFNs and TALENs and has revolutionized the biotechnology field ( Zhang et al., 2021 ; Tran et al., 2022 ). The Cas9/sgRNA complex produces site-specific DNA double-strand breaks (DSBs), stimulating homology-directed repair (HDR) or non-homologous end joining (NHEJ) pathways to achieve genome editing.
HDR is an accurate but inefficient mechanism, which utilizes a homologous donor template to repair DNA cleavages ( Li et al., 2019 ; Fu et al., 2021 ). By contrast, the error-prone NHEJ mechanism introduces small insertions and deletions (indels) and the exact sequence changes are unpredictable and uncontrollable ( Fu et al., 2021 ).
- When the indels are deposited at the coding sequences of a given gene, NHEJ can cause frameshift mutations, resulting in non-sense-mediated mRNA decay and gene silencing ( Wang et al., 2016a ; Zischewski et al., 2017 ; Lindeboom et al., 2019 ).
- Although CRISPR/Cas systems exhibit tremendous potential in translational medicine, off-target effects remain a major challenge ( Fu et al., 2013 ; Hsu et al., 2013 ; Pacesa et al., 2022 ).
The off-target effects occur when Cas9 acts on untargeted genomic sites and creates cleavages that may lead to adverse outcomes. The off-target sites are often sgRNA-dependent, since Cas9 is known to tolerate up to 3 mismatches between sgRNA and genomic DNA ( Fu et al., 2013 ; Hsu et al., 2013 ; Wang et al., 2016a ).
- In this scenario, in silico tools are useful to search for potential off-target sites in the whole genome and calculate the likelihood of an off-target editing ( Naeem et al., 2020 ).
- Nevertheless, accumulative studies have proved that sgRNA-independent off-target effects also exist, urging unbiased experimental detection and validation ( Richter et al., 2020 ; O’Geen et al., 2015 ).
In this review, we summarize available methods for the assessment of off-target effects, indicating their advantages versus limitations. Some of these detection methods for off-targets prediction is applicable for other family of Cas nucleases, such as Cas12a (Cpf1), which also create DSBs on off-target sites ( Kim et al., 2019 ).
What is target slang?
(slang) to have someone to have sex.
What is off-target testing
Samsung Research Software systems powering OS kernels, basebands, bootloaders, firmware, IoT or automotive build the foundation of infrastructure that billions of people rely on every day. Testing these systems is crucial, especially as their complexity grows and they are often written in unsafe languages such as C/C++.
- However, testing such complex systems poses significant challenges, e.g., custom hardware for which there is no emulator, or a non-trivial setup of testing and debugging on the target device.
- As a result, the commonly used testing techniques and tools are not always easily applicable.
- An off-target (OT) testing is a promising technique which addresses these challenges: part of the code is extracted and adapted to run on a different hardware platform with better tool support, easier debugging and higher test throughput.
Unfortunately, since the process of creating an OT program has been manual, the technique did not scale well and was mostly used in an ad-hoc manner. In this paper we present a novel complex systems testing approach called Auto Off-target (AoT). Based on the information extracted from the source code and from the build process, AoT can automatically generate OT programs in C.
AoT goes beyond the code generation and provides mechanisms that help to recreate and discover the program state in the OT code. The generated OTs are self-contained and independent of the original build environment. As a result, pieces of complex or embedded software can be easily run, analyzed, debugged and tested on a standard x86_64 machine.
We evaluate AoT on tens of thousands of functions selected from OS kernels, a bootloader and a network stack. We demonstrate that majority of the generated OTs can be automatically tested with fuzzing and symbolic execution. We further used AoT in a bug finding campaign and discovered seven bugs in the Android Redfin and Oriole kernels : Samsung Research
What does off-target mean genetics
From Wikipedia, the free encyclopedia Off-target genome editing refers to nonspecific and unintended genetic modifications that can arise through the use of engineered nuclease technologies such as: clustered, regularly interspaced, short palindromic repeats ( CRISPR )- Cas9, transcription activator-like effector nucleases ( TALEN ), meganucleases, and zinc finger nucleases (ZFN).
These tools use different mechanisms to bind a predetermined sequence of DNA (“target”), which they cleave (or “cut”), creating a double-stranded chromosomal break (DSB) that summons the cell’s DNA repair mechanisms (non-homologous end joining ( NHEJ ) and homologous recombination ( HR )) and leads to site-specific modifications.
If these complexes do not bind at the target, often a result of homologous sequences and/or mismatch tolerance, they will cleave off-target DSB and cause non-specific genetic modifications. Specifically, off-target effects consist of unintended point mutations, deletions, insertions inversions, and translocations,
- Designer nuclease systems such as CRISPR-cas9 are becoming increasingly popular research tools as a result of their simplicity, scalability and affordability.
- With this being said, off-target genetic modifications are frequent and can alter the function of otherwise intact genes.
- Multiple studies using early CRISPR-cas9 agents found that greater than 50% of RNA-guided endonuclease-induced mutations were not occurring on-target.
The Cas9 guide RNA (gRNA) recognizes a 20 bp target DNA sequence, which it binds and cleaves to “edit” the DNA sequence. However, target sequence binding can tolerate mismatches up to several base pairs, meaning there are often thousands of possible binding sites which present several experimental and safety concerns.
- In the research sphere, off-target effects can confound variables in biological studies leading to potentially misleading and non-reproducible results.
- In the clinical sphere, the major concerns surround the disruption of vital coding regions leading to genotoxic effects such as cancer.
- Accordingly, the improvement of the specificity of genome editing tools and the detection of off-target effects are rapidly progressing research areas.
Such research incorporates designer nuclease development and discovery, computational prediction programs and databases, and high-throughput sequencing to reduce and anticipate mutational occurrence. Many designer nuclease tools are still in their relative infancy and as their molecular properties and in vivo behaviors become better understood they will become increasingly precise and predictable.
What are off-target changes and why are they worrisome
Translocation and Other Chromosomal Aberration Detection – Off-target mutations and insertional mutagenesis are considered to be harmful because they can perturb the expression of nearby genetic elements by means of different mechanisms (McCormack and Rabbitts, 2004 ).
While this dysregulation is usually localized, rare or innocuous, major concerns derive from general genomic instability and the several chromosomal aberrations that we may or may not detect after editing. Increasing evidences are showing how those gross chromosomal aberrations generate after designer nucleases activity (Weinstock et al., 2008 ; Kosicki et al., 2018 ; Turchiano et al., 2020 ).
Oncongenic translocations have been reproduced in vivo in lung tissues of mouse models by the simultaneous introduction of two DSBs, confirming this major concern (Blasco et al., 2014 ). Large deletions, loss of heterozygosity, large inversions, or translocations may also impact the 3D genomic organization and cause dysregulations of entire topological associated domains (median size ~880 kb) usually organized to be transcriptionally active or repressed (Dixon et al., 2012 ; Bonev and Cavalli, 2016 ).
Recent studies also observed on-target related chromosomal aberrations with formation of micronuclei and chromosome bridges leading to copy number variation, telomeric portion loss, and chromotripsis (Cullot et al., 2019 ; Leibowitz et al., 2020 ) rising further concerns for the safety of designer nucleases in clinic.
The portfolio of translocation detection techniques developed to recognize those mutations with increasing sensitivity comprises TC-seq (translocation capture sequencing; Klein et al., 2011 ), UDiTaS (UniDirectional Targeted Sequencing; Giannoukos et al., 2018 ), AMP-seq (anchored multiplexed PCR sequencing; Zheng et al., 2014 ), LAM-HTGTS (linear amplification-mediated high-throughput genome-wide sequencing; Frock et al., 2015 ), and CAST-seq (chromosomal aberration analysis by single targeted LM-PCR sequencing; Turchiano et al., 2020 ).
- All of these methods are based on nested PCRs with primers binding between a known target site and fused unknown sites marked by an adapter.
- NGS sequencing is then used to identify the fusion partners.
- Differences among these techniques include in particular the adapter attachment via tagmentation (UDiTas), bridge adaptor ligation (LAM-HTGTS), or dsDNA ligation (CAST-seq and AMP-seq).
Besides, the amount of input DNA and the bioinformatic pipeline can differ substantially for these techniques as shown in Supplementary Table 3, For designer nucleases, the validation of translocation sites can be performed by looking for off-target cleavage at the fused sites by deep sequencing.
What is a Target notification?
When an item is out of stock, we may offer the option to receive notifications when it’s back in stock. If this is available for an item, the Target.com product details page will display a notify me when it’s back button. If you’re using the Target app, it will be a notify me button.
- You’ll need to sign in to your Target.com account in order to sign up for notifications.
- When signing up for notifications on Target.com, you’ll receive the notification via email.
- If you’re using the Target app, you’ll receive a push notification to your mobile device.
- Opting in to receive notifications doesn’t reserve or guarantee item availability, so you may want to act fast in the event the item goes out of stock again.
Exclusions may apply for high demand or limited items. The notification feature doesn’t apply to store inventory. To unsubscribe from notifications, select unsubscribe on Target.com, or don’t notify me in the Target app.
How do I stop Target emails
9. How is Your Personal Information Protected? – We maintain administrative, technical, and physical safeguards to protect your personal information. When we collect or transmit sensitive information such as a credit or debit card number, we use Payment Card Industry (PCI) standards to protect that information.
- However, no e-commerce solution, website, mobile application, database or system is completely secure or “hacker proof.” You are also responsible for taking reasonable steps to protect your personal information against unauthorized disclosure or misuse.
- We recognize the particular importance of protecting privacy where children are involved.
We do not knowingly collect personal information online from children under the age of 13. If a child under the age of 13 has provided us with personal information online, we ask that a parent or guardian call the privacy information line at 1-800-831-6880,
- Back to Top 10.
- Automated License Plate Recognition Technology We may use Automated License Plate Recognition (ALPR) technology where not prohibited by law to collect information relating to vehicles present at or near Target stores.
- We collect, use, and share this information for fraud prevention, security, and assets protection.
Access and use of the ALPR technology and information collected is restricted to Target team members or contractors who are fulfilling one of the specified purposes, including assets protection, investigations, technology and legal teams. These authorized users receive data security training that includes information on access controls and other measures to protect confidential information.
- Use of the ALPR technology is overseen by an Assets Protection Director in collaboration with Target’s privacy and data security compliance teams.
- Periodic system audits are done to review data accuracy, system access, and retention.
- ALPR Information is stored for approximately 30 days before it is permanently deleted unless the information is retained for investigative or legal purposes.
ALPR information is not sold, but may be disclosed when we believe it is appropriate to comply with the law or to protect the rights, property, or safety of our company, our Guests, or others. Back to Top
Can I turn off all notifications
Turn off notifications from device settings – From your Android device’s Settings, you can turn off notifications by following these steps.1. Open Settings, tap Notifications, and then App notifications. 2. Under Most recent, select the application you want to make notification changes to. (To find more apps, tap All apps from the dropdown menu. Select the app.) 3. Turn on or off the selected app’s notifications. You can either turn off all notifications or pick specific categories that you want the app to show notifications for.
What does turn off mean on a computer?
From Wikipedia, the free encyclopedia Windows XP shutdown dialog box Windows 10 power menu, opened from the Start Menu To shut down or power off a computer is to remove power from a computer’s main components in a controlled way. After a computer is shut down, main components such as CPUs, RAM modules and hard disk drives are powered down, although some internal components, such as an internal clock, may retain power.
Does always on display turn off when phone is face down?
Keep the iPhone display on longer On iPhone 14 Pro, iPhone 14 Pro Max, iPhone 15 Pro, and iPhone 15 Pro Max, the Always-On display setting allows a dimmed version of your Lock Screen to stay visible, even when your iPhone is locked. By glancing at the dimmed screen, you can check essential information, like notifications, the date and time, and information in your widgets. The display automatically turns off when iPhone is either face down or obstructed from view, not near a paired Apple Watch, when a CarPlay session begins, while Continuity Camera is in use, while is on, while is on, or at your usual bedtime. The Always-On display setting is on by default. To turn it off, go to Settings > Display & Brightness, then turn off Always On Display. Tip: When Always-On display is turned on, you can choose whether to show your wallpaper or notifications on your Lock Screen. In Settings > Display & Brightness > Always On Display, turn Show Wallpaper or Show Notifications on or off. : Keep the iPhone display on longer
What does Odin mode mean on Samsung?
From Wikipedia, the free encyclopedia
Odin 3.14 running on a Windows 11 machine, with a device ready for flashing plugged in. | |
Developer(s) | Samsung |
---|---|
Stable release | 3.14.1 / February 2020 ; 3 years ago |
Operating system | Windows |
Available in | English |
Odin is a utility software program developed and used by Samsung internally which is used to communicate with Samsung devices in Odin mode (also called download mode ). It can be used to flash a custom recovery firmware image (as opposed to the stock recovery firmware image) to a Samsung Android device,
Odin is also used for unbricking certain Android devices. Odin is the Samsung proprietary alternative to Fastboot, There is no account of Samsung ever having officially openly released Odin, though it is mentioned in the developer documents for Samsung Knox SDK and some documents even instruct users to use Odin.
Some other docs on Knox SDK reference “engineering firmware”, which presumably can be a part of the Knox SDK along with Odin. Publicly available binaries are believed to be the result of leaks. The tool is not intended for consumers, but for Samsung’s own personnel and approved repair centers.
How do I fix my Samsung stuck in Odin mode?
2. How To Exit Odin Mode – For exiting the Odin Mode on your Samsung smartphone, follow the simple process as guided next to exit the device according to the respective model: For Samsung Devices with Home Button: Simply press the “Power” button until it restarts the device in a normal state.
- For Samsung Devices With Bixby Button: Press and hold the “Volume Down” and “Power” button until the phone shuts off and reboots in a normal state.
- For Samsung Devices With Volume and Power Button: You will have to press and hold the “Volume Down” and “Power” buttons for 7 seconds until the device restarts.
However, if these techniques do not help you come out of the Samsung Odin Mode and Odin fail error persists, you are advised to try the methods given in the other sections of this article, before you do that, it is necessary to take a complete back-up of your data, media and other files, stored in your Samsung device because making any changes to the firmware while fixing the problem could wipe off your data.
Backing up your data will prevent data loss and will provide blanket protection just in case you lose any data while fixing the Odin fail error. Wondershare Dr.Fone comes as a great tool to back up your data with just a single click on your PC. You may try it for free and use all its features before purchasing the product.
This software enables you to back up and restores all types of data such as photos, videos, contacts, audio files, apps, documents, notes, memos, calendars, call logs, and much more.